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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Capsaicin, TNF-related apoptosis inducing ligand
Phytochemical Name Capsaicin (PubChem CID: 1548943 )
Anticancer drug Name TNF-related apoptosis inducing ligand (PubChem CID: / )
Structure of
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 833
Ref_1
Pair Name Capsaicin, TNF-related apoptosis inducing ligand
Disease Info [ICD-11: 2A00] Glioblastoma multiforme Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Down-regulation Expression BIRC5 hsa332
Down-regulation Expression CCNB1 hsa891
Down-regulation Expression POLD1 hsa5424
Up-regulation Expression TNFRSF10B hsa8795
In Vitro Model U-87MG ATCC Glioblastoma Homo sapiens (Human) CVCL_0022
U-343MG Glioblastoma Homo sapiens (Human) CVCL_S471
T98G Glioblastoma Homo sapiens (Human) CVCL_0556
SNU-444 Glioblastoma Homo sapiens (Human) CVCL_5060
U-251MG Astrocytoma Homo sapiens (Human) CVCL_0021
Result A combined regimen using capsaicin and TRAIL may provide a safe and effective strategy for treating malignant gliomas.
03. Reference
No. Title Href
1 Capsaicin sensitizes malignant glioma cells to TRAIL-mediated apoptosis via DR5 upregulation and survivin downregulation. Carcinogenesis. 2010 Mar;31(3):367-75. doi: 10.1093/carcin/bgp298. Click
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